Serum and sputum neurotrophin levels in chronic persistent cough.

  title={Serum and sputum neurotrophin levels in chronic persistent cough.},
  author={Rekha Chaudhuri and Alex D. McMahon and Charles P McSharry and K J Macleod and Iona Fraser and Eric E. Livingston and Neil C Thomson},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={35 7},
BACKGROUND Neurotrophins (NTs) are a family of growth factors, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin3 (NT-3) that are involved in inflammation. Serum and induced sputum NT levels are increased in asthma and in cough because of idiopathic pulmonary fibrosis, respectively. Neurogenic inflammation is implicated in the pathogenesis of chronic cough in individuals with normal chest radiography, but the role of NTs in this condition is unknown… CONTINUE READING


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