Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response.

@article{Aoyama2005SerumAG,
  title={Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response.},
  author={Takuma Aoyama and Takashi Matsui and Mikhail Novikov and Jongsun Park and Brian Hemmings and Anthony Rosenzweig},
  journal={Circulation},
  year={2005},
  volume={111 13},
  pages={1652-9}
}
BACKGROUND Serum- and glucocorticoid-responsive kinase-1 (SGK1), a serine-threonine kinase that is highly expressed in the heart, has been previously reported to regulate sodium channels. Because SGK1 is a PI 3-kinase-dependent kinase with structural homology to Akt, we examined its regulation in the heart and its effects on cardiomyocyte (CM) apoptosis and hypertrophy in vitro. METHODS AND RESULTS Rats were subjected to aortic banding, and expression of total and phosphorylated SGK1 was… CONTINUE READING
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Adenoviral expression of activated PI3-kinase rescues detrimental effects of chronic cardiac-specific Akt activation

  • T Nagoshi, T Matsui, HC Champion, L Li, A. Rosenzweig
  • Circulation. 2004;110(suppl III):III-285…
  • 2004

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