Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A.

  title={Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A.},
  author={Christoph Boehmer and Viktoria Wilhelm and M{\`o}nica Palmada and Sabine Wallisch and Guido Henke and Heinrich Brinkmeier and Philip S. Cohen and Burkert Pieske and Florian Lang},
  journal={Cardiovascular research},
  volume={57 4},
The serum and glucocorticoid inducible kinase SGK1 and its isoform SGK3 are both expressed in cardiac tissue. One of the functions of SGK1 is the phosphorylation and inactivation of the ubiquitin ligase Nedd4-2, which in turn could be shown to downregulate the voltage-gated Na+ channel SCN5A (hH1). The present study has been performed to test for a role of SGK1 and SGK3 in the regulation of SCN5A. To this end cRNA encoding the human Na+ channel SCN5A was injected into Xenopus laevis oocytes… CONTINUE READING

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