Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.

@article{Schmidt2012SerumAG,
  title={Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.},
  author={Eva-Maria Schmidt and Shuchen Gu and Vasileia Anagnostopoulou and Konstantinos Alevizopoulos and Michael F{\"o}ller and Florian Lang and Constantine Stournaras},
  journal={The FEBS journal},
  year={2012},
  volume={279 7},
  pages={
          1231-42
        }
}
The serum- and glucocorticoid-dependent kinases 1-3 (SGK1-3) are downstream effectors of phosphatidylinositol 3-kinases, implicated in various cell responses including colon cancer tumorigenesis in mice. Here, we investigated the role of SGK1 in the regulation of cell motility. Using Caco-2 colon tumor and HEK293 embryonic kidney cells, we report that transfection with the constitutively active SGK1 mutant (SGK1-SD) significantly enhanced cell motility. The cell-adhesion protein vinculin was… CONTINUE READING
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