Serum and epidermal growth factor transiently depolarize quiescent BSC-1 epithelial cells.

@article{Rothenberg1982SerumAE,
  title={Serum and epidermal growth factor transiently depolarize quiescent BSC-1 epithelial cells.},
  author={Paul Rothenberg and Luis Reuss and Luis Glaser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 24},
  pages={7783-7}
}
Continuous intracellular recording of membrane potential with microelectrodes in BSC-1 epithelial cells has been used to study the early ionic effects of the interaction of mitogens with cell surface receptors. Initial results show that (i) there is no significant difference in membrane potential between growing and quiescent cells, (ii) addition of epidermal growth factor or serum to quiescent BSC-1 cells induces a brief and transient depolarization, (iii) the mitogenic response of BSC-1 cells… CONTINUE READING