Serum and Quantitative Electroencephalographic Pharmacokinetics of Loprazolam in the Elderly

@article{Mamelak1988SerumAQ,
  title={Serum and Quantitative Electroencephalographic Pharmacokinetics of Loprazolam in the Elderly},
  author={Mortimer Mamelak and P. Bunting and Howard Galin and V Price and Adele C Csima and Trevor Young and Dwora Klein and Jocelyn R. Pelchat},
  journal={The Journal of Clinical Pharmacology},
  year={1988},
  volume={28}
}
This study was undertaken to determine the serum pharmacokinetic parameters of loprazolam, a new benzodiazepine hypnotic, in elderly subjects and to compare these with the kinetics of the drug as determined by quantitative EEG analysis. In addition, a 14‐day study was undertaken to determine the steady‐state serum levels achieved in this population with repeated drug administration. The study was conducted on 16 male and female subjects between the ages of 62 and 72 years, randomly assigned to… 
Benzodiazepine hypnotics in the elderly
  • P. Cook
  • Psychology, Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 1986
TLDR
Control studies in which subjects of different ages have received single doses of diazepam have consistently shown an increase in the response to benzodiazepines in the elderly which is not explained by the effects of disease or by altered plasma concentrations.
Impairment of memory and plasma flunitrazepam levels
TLDR
Results indicate that higher concentrations were needed to impair attention than were required to impair memory, and there was a significant positive correlation between peak levels of flunitrazepam at night and impairment of night attention and explicit memory.
Pharmacokinetics of temazepam compared with other benzodiazepine hypnotics—some clinical consequences
TLDR
In hypnotic treatment, the duration of drug action should be restricted to theduration of the night, hence a compound with a relatively short elimination half‐life may represent a more rational choice.

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