Serum and CSF N-acetyl aspartate levels differ in multiple sclerosis and neuromyelitis optica.

@article{Tortorella2011SerumAC,
  title={Serum and CSF N-acetyl aspartate levels differ in multiple sclerosis and neuromyelitis optica.},
  author={Carla Tortorella and Maddalena Ruggieri and Elisabetta Di Monte and Edmondo Ceci and Piero Iaffaldano and Vita Direnzo and Mariangela Mastrapasqua and Antonio Frigeri and Maria Pia Amato and Bahia Hakiki and Angelo Ghezzi and Alessandra Lugaresi and Giovanna de Luca and Francesco Patti and E D'Amico and Patrizia Sola and Anna Maria Simone and Maria Svelto and Paolo Livrea and Maria Trojano},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2011},
  volume={82 12},
  pages={1355-9}
}
BACKGROUND The identification of biomarkers able to improve the differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica (NMO) is challenging because of a different prognosis and response to treatment. Growing evidence indicates that brain and CSF N-acetyl aspartate (NAA) concentration is a useful marker for characterising different phases of axonal pathology in demyelinating diseases, and preliminary studies suggest that increased serum NAA levels may be a telltale sign… CONTINUE READING
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