Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity

  title={Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity},
  author={M.C.M. Bickerstaff and Marina Botto and Winston L. Hutchinson and Jeff Herbert and Glenys A Tennent and Alison Bybee and Daniel A. Mitchell and H Terence Cook and P W Butler and Mark J. Walport and Mark B Pepys},
  journal={Nature Medicine},
Serum amyloid P component (SAP), a highly conserved plasma protein named for its universal presence in amyloid deposits, is the single normal circulating protein that shows specific calcium-dependent binding to DNA and chromatin in physiological conditions. The avid binding of SAP displaces H1-type histones and thereby solubilizes native long chromatin, which is otherwise profoundly insoluble at the physiological ionic strength of extracellular fluids. Furthermore, SAP binds in vivo both to… CONTINUE READING
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Homozygous C 1 q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

  • M. Botto
  • Nature Genet .
  • 1998

Amyloid P component . A critical review

  • M. B. Pepys
  • Amyloid : Int . J . Exp . Clin . Invest .
  • 1997

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