Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts.

@article{Migita1998SerumAA,
  title={Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts.},
  author={Kiyoshi Migita and Yojiro Kawabe and Mitsutoshi Tominaga and Tomoki Origuchi and Takahiko Aoyagi and Katsumi Eguchi},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1998},
  volume={78 5},
  pages={535-9}
}
Serum amyloid A (SAA) is a precursor protein for amyloid A, which is a constituent for amyloid fibrils in secondary amyloidosis. To determine the role of SAA in the articular destruction in patients with rheumatoid arthritis (RA), we investigated the effects of SAA on the production of matrix metalloproteinases (MMPs) by rheumatoid synovial fibroblasts. SAA stimulated rheumatoid synovial fibroblasts to produce MMP-2 and MMP-3 in a dose-dependent manner. Pretreatment of synovial fibroblasts with… CONTINUE READING
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