Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti-Candida activity.

@article{Badolato2000SerumAA,
  title={Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti-Candida activity.},
  author={Raffaele Badolato and Ji ming Wang and Sarah Stornello and Alessandro Negro Ponzi and Marzia Duse and Tiziana Musso},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={67 3},
  pages={381-6}
}
Serum amyloid A (SAA) is a 12-kDa protein secreted in large amounts by liver cells during microbial infections or inflammatory diseases. We have recently reported that SAA induces chemotaxis of polymorphonuclear cells (PMN), monocytes, and T lymphocytes and stimulates their adhesion to endothelial monolayers. In this study, we investigated whether SAA regulates PMN antimicrobial activities. We found that recombinant SAA (rSAA), at concentrations comparable to serum levels attained during an… CONTINUE READING