Serum amyloid A in uremic HDL promotes inflammation.

  title={Serum amyloid A in uremic HDL promotes inflammation.},
  author={Thomas Weichhart and Chantal Kopecky and Markus Kubicek and Michael Haidinger and Dominik D{\"o}ller and Karl Katholnig and Cacang Suarna and Philipp Eller and Markus Toelle and Christopher Gerner and Gerhard J Zlabinger and Markus van der Giet and Walter Hermann H{\"o}rl and Roland Stocker and Marcus D. S{\"a}emann},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={23 5},
Uremia impairs the atheroprotective properties of HDL, but the mechanisms underlying why this occurs are unknown. Here, we observed that HDL isolated from healthy individuals inhibited the production of inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist. In contrast, HDL isolated from the majority of patients with ESRD did not show this anti-inflammatory property; many HDL samples even promoted the production of inflammatory cytokines. To investigate… CONTINUE READING


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HDL in humans with cardiovascular disease exhibits a proteomic signature.

Clinica chimica acta; international journal of clinical chemistry • 2010

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