Serum amyloid A complexed with extracellular matrix induces the secretion of tumor necrosis factor-α by human T-lymphocytes

Abstract

Serum amyloid A (SAA), an acute-phase reactant, exists naturally as a minor protein in the sera of healthy individuals. However, its levels in sera are increased markedly during various transient and chronic inflammatory diseases, often concomitantly with accumulation at inflicted sites. SAA is synthesized mainly in the liver following the synergistic… (More)
DOI: 10.1007/BF02443485

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