Serum amyloid A binds specific extracellular matrix glycoproteins and induces the adhesion of resting CD4+ T cells.

@article{PreciadoPatt1996SerumAA,
  title={Serum amyloid A binds specific extracellular matrix glycoproteins and induces the adhesion of resting CD4+ T cells.},
  author={Liana Preciado-Patt and Rami Hershkoviz and Mati Fridkin and Ofer Lider},
  journal={Journal of immunology},
  year={1996},
  volume={156 3},
  pages={1189-95}
}
Serum amyloid A (SAA), a prototypic acute phase protein reactant, exists naturally in the serum of healthy individuals. However, the levels of SAA in serum and its presence in sites of inflammation increase during certain chronic diseases associated with a local elevation of cytokine concentrations. Although the chemical structure of SAA is defined, its putative immunologic role(s) is still obscure. Nevertheless, it has been shown that 1) SAA acts as a chemoattractant and regulator of the… CONTINUE READING