Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases.

@article{Baranova2005SerumAA,
  title={Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases.},
  author={Irina N Baranova and Tatyana G. Vishnyakova and Alexander V Bocharov and Roger J. Kurlander and Zhigang Chen and Michael L Kimelman and Alan T Remaley and Gyorgy Csako and Fairwell Thomas and Thomas L. Eggerman and Amy P. Patterson},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={8031-40}
}
Serum amyloid A protein (SAA) is an acute-phase reactant, known to mediate pro-inflammatory cellular responses. This study reports that CLA-1 (CD36 and LIMPII Analogous-1; human orthologue of the Scavenger Receptor Class B Type I (SR-BI)) mediates SAA uptake and downstream SAA signaling. Flow cytometry experiments revealed more than a 5-fold increase of Alexa-488 SAA uptake in HeLa cells stably transfected with CLA-1. Alexa 488-HDL uptake directly correlated with SAA uptake when determined in… CONTINUE READING

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hp://w w w .jb.org/ D

  • R. L. Meek, N. Eriksen, E. P. Benditt
  • J. Biol. Chem. 10.1074/jbc.M405009200
  • 1992

Virch

  • B. Kluve-Beckerman, J. J. Manaloor, J. J. Liepnieks
  • Arch . A Pathol . Anat . Histopathol .
  • 1989

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