Serum amyloid A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases.

@article{Vallon2001SerumAA,
  title={Serum amyloid A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases.},
  author={R{\"u}diger D W Vallon and Felix Freuler and Netsanet Desta-Tsedu and Anna S Robeva and Janet Dawson and Peter Wenner and Petra Engelhardt and Ludwig Boes and J{\"o}rg Schnyder and Claude Tschopp and Roman Urfer and G{\"o}tz Baumann},
  journal={Journal of immunology},
  year={2001},
  volume={166 4},
  pages={2801-7}
}
The acute-phase reactant rabbit serum amyloid A 3 (SAA3) was identified as the major difference product in Ag-induced arthritis in the rabbit, a model resembling in many aspects the clinical characteristics of rheumatoid arthritis (RA) in humans. In Ag-induced arthritis, up-regulated SAA3 transcription in vivo was detected in cells infiltrating into the inflamed joint, in the area where pannus formation starts and, most notably, also in chondrocytes. The proinflammatory cytokine IL-1beta… CONTINUE READING

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