Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner.

@article{Wilson2008SerumAA,
  title={Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner.},
  author={Patricia G Wilson and Joel C. Thompson and Nancy R. Webb and Frederick C. de Beer and Victoria L. King and Lisa R. Tannock},
  journal={The American journal of pathology},
  year={2008},
  volume={173 6},
  pages={1902-10}
}
Inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) are predictive of cardiac disease and are proposed to play causal roles in the development of atherosclerosis, in which the retention of lipoproteins by vascular wall proteoglycans is critical. The purpose of this study was to determine whether SAA and/or CRP alters vascular proteoglycan synthesis and lipoprotein retention in a pro-atherogenic manner. Vascular smooth muscle cells were stimulated with either SAA or CRP (1 to… CONTINUE READING
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