Serum alpha1-proteinase inhibitor concentrations in healthy dogs--method validation and determination of reference interval and intra-individual variation.

@article{Heilmann2013SerumAI,
  title={Serum alpha1-proteinase inhibitor concentrations in healthy dogs--method validation and determination of reference interval and intra-individual variation.},
  author={Romy M Heilmann and Craig G Ruaux and Iwan A Burgener and Jennifer D Hern and Jan S Suchodolski and Joerg M Steiner},
  journal={Veterinary clinical pathology},
  year={2013},
  volume={42 2},
  pages={
          190-5
        }
}
BACKGROUND A chronic loss of canine α1 -proteinase inhibitor (cα1 -PI) into the gastrointestinal (GI) tract could change the systemic proteinase-proteinase inhibitor balance. Serum cα1 -PI concentrations have not been studied in dogs with well-defined GI diseases. OBJECTIVES To further evaluate serum cα1 -PI concentrations in dogs with GI diseases, the objectives of this study were to (1) analytically validate a previously developed fecal cα1 -PI immunoassay to determine serum concentrations… CONTINUE READING
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