Serum albuterol levels in mechanically ventilated patients and healthy subjects after metered-dose inhaler administration.

@article{Duarte1996SerumAL,
  title={Serum albuterol levels in mechanically ventilated patients and healthy subjects after metered-dose inhaler administration.},
  author={Alex G. Duarte and Rajiv Dhand and Ralph Reid and James B. Fink and Patrick J. Fahey and Martin J. Tobin and John W. Jenne},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={154 6 Pt 1},
  pages={
          1658-63
        }
}
In mechanically ventilated patients, systemic blood levels of inhaled drugs reflect absorption from the lower respiratory tract alone since, unlike nonintubated patients, oropharyngeal and gastrointestinal absorption cannot occur. To determine the efficiency of aerosol administration by a metered-dose inhaler (MDI), we measured serum albuterol levels after administration by a MDI and spacer to nine mechanically ventilated patients (10 puffs) and to 10 healthy subjects (six puffs). Serum… CONTINUE READING

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