Serum albumin enhances polyethylenimine-mediated gene delivery to human respiratory epithelial cells.

@article{Carrabino2005SerumAE,
  title={Serum albumin enhances polyethylenimine-mediated gene delivery to human respiratory epithelial cells.},
  author={Salvatore Carrabino and Sante Di Gioia and Elena Copreni and Massimo Conese},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 12},
  pages={1555-64}
}
BACKGROUND The interaction of polyethylenimine (PEI) polyplexes with proteins in cystic fibrosis (CF) airway secretions poses a significant hurdle to this nonviral delivery system. The aim of this study was to evaluate whether albumin may increase the efficiency of PEI complexes in mediating gene transfer into respiratory epithelial cells in the presence of CF mucus. METHODS PEI (25 kDa) was complexed to DNA in the presence of human serum albumin (HSA) and used to transfect confluent A549 and… CONTINUE READING
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