Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration.

@article{Catacuzzeno2011SerumactivatedKA,
  title={Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration.},
  author={Luigi Catacuzzeno and Francesco Aiello and Bernard Fioretti and Luigi Sforna and Emilia Castigli and P. Ruggieri and Ada Maria Tata and Antonella Calogero and Fabio Franciolini},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 7},
  pages={1926-33}
}
Glioblastoma cells in vivo are exposed to a variety of promigratory signals, including undefined serum components that infiltrate into high grade gliomas as result of blood-brain barrier breakdown. Glioblastoma cell migration has been further shown to depend heavily on ion channels activity. We have then investigated the modulatory effects of fetal calf serum (FCS) on ion channels, and their involvement in U87-MG cells migration. Using the perforated patch-clamp technique we have found that, in… CONTINUE READING