Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1.

@article{Levy1994SerumVR,
  title={Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1.},
  author={David N Levy and Yosef Refaeli and Rob Roy Macgregor and David B. Weiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 23},
  pages={10873-7}
}
In human immunodeficiency virus (HIV)-positive individuals, the vast majority of infected peripheral blood cells and lymph node cells may be latently or nonproductively infected. The vpr open reading frame of HIV-1 encodes a 15-kDa virion-associated protein, Vpr. The vpr gene has been shown to increase virus replication in T cells and monocyte/macrophages in vitro. We have previously reported that vpr expression in various tumor lines leads to growth inhibition and differentiation, indicating… CONTINUE READING
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