Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes

@article{Youn2008SerumVC,
  title={Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes},
  author={Byung-Soo Youn and Nora Kl{\"o}ting and J{\"u}rgen Kratzsch and Nam Seok Lee and Ji Woo Park and E Song and Karen Ruschke and Andreas Oberbach and Mathias Fasshauer and Michael Stumvoll and Matthias Bl{\"u}her},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={372 - 377}
}
OBJECTIVE— Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS— For the measurement of vaspin serum concentrations, we… 
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Highly Influential Citations
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Methods Citations
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Vaspin in obesity and diabetes: pathophysiological and clinical significance
TLDR
Identification of the proteases, which are inhibited by vaspin may lead to the development of novel strategies in the treatment of obesity, diabetes and insulin resistance.
Vaspin concentration in obesity, impaired glucose tolerance and Type 2 diabetes in Egypt
TLDR
Serum vaspin level was significantly higher in obese and prediabetic subjects, significantly Higher in predi diabetic obese than normal obese, and significantlyHigher in females of obese and control groups compared with males of the same groups, and it decreased with duration of diabetes.
Vaspin in type 2 diabetes in relation to atherosclerosis
TLDR
Serum vaspin was shown to be significantly lower in T2D patients with a longer duration of illness, and an increased carotid intima-media thickness in diabetic patients was not related to thevaspin level, denoting an underlying combining factor for atherosclerosis in diabetic Patients other than vaspIn.
Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes.
TLDR
Serum vaspin levels were significantly elevated in obese people and were independently associated with WHR, gender, and index sensitivity index, as well as with body mass index, waist-to-rip ratio (WHR), fat percentage, triglyceride, fasting plasma insulin, and insulin sensitivity index.
Serum vaspin levels in type 2 diabetic women in relation to microvascular complications.
TLDR
Diabetic women with good glycemic control have lower levels of vaspin than those with poor gly glucose control, however, presence of microvascular complications is also associated with low vaspIn levels.
Serum Vaspin Concentrations in Relation to Insulin Sensitivity Following RYGB-Induced Weight Loss
TLDR
Following RYGB surgery, changes in serum vaspin concentrations correlate significantly with the reduction of circulating leptin, insulin, and C-peptide levels and with the amelioration of insulin sensitivity.
Low Circulating Vaspin Level is not associated with Insulinemic Status in Impaired Glucose Tolerant Subjects
TLDR
It may be concluded that low circulating vaspin level is not associated with insulinemic status in impaired glucose tolerant subjects.
Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans.
TLDR
The results support the existence of a sexual dimorphism regarding circulating vaspin regarding insulin sensitivity in nondiabetic humans, and the lack of an association of serum vaspIn with HOMA-IR and M value indicates, however, no major role for vasp in concerning insulin sensitivityIn nondi diabetic humans.
Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance
TLDR
Vaspin is a predictor of MetS as a single entity, independent of obesity, largely ascribed to the effects of insulin resistance and chronic inflammation.
Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications
TLDR
Serum vaspin may be considered as a potential marker to assess the status of elderly patients with T2DM and the risk of developing serious macrovascular complications, and Logistic regression analysis revealed that serum vaspIn concentration, systolic blood pressure, HDL-C and T1DM duration were independent influencing factors for diabetic macrov vascular complications.
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