Serum Valproate Levels with Oral Contraceptive Use

  title={Serum Valproate Levels with Oral Contraceptive Use},
  author={A. Herzog and E. L. Farina and A. Blum},
  • A. Herzog, E. L. Farina, A. Blum
  • Published 2005
  • Medicine
  • Epilepsia
  • It has long been recognized that the use of the older enzyme-inducing antiepileptic drugs (AEDs), such as barbiturates, phenytoin (PHT) and carbamazepine (CBZ), is associated with higher failure rates of oral contraceptive pills (OCPs), likely because of the induction of the catabolism and binding of reproductive steroids (1). A newer enzyme-inducing AED, topiramate (TPM), also has been shown to reduce serum OCP steroid levels at daily dosages of ≥200 mg (2). Clinically significant interactions… CONTINUE READING
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