• DOI:10.1111/j.1528-1167.2005.00605.x
Corpus ID: 7696039

Serum Valproate Levels with Oral Contraceptive Use

@article{Herzog2005SerumVL,
  title={Serum Valproate Levels with Oral Contraceptive Use},
  author={A. Herzog and E. L. Farina and A. Blum},
  journal={Epilepsia},
  year={2005},
  volume={46}
}

A. Herzog, E. L. Farina, A. Blum

Published 2005

Medicine

Epilepsia

It has long been recognized that the use of the older enzyme-inducing antiepileptic drugs (AEDs), such as barbiturates, phenytoin (PHT) and carbamazepine (CBZ), is associated with higher failure rates of oral contraceptive pills (OCPs), likely because of the induction of the catabolism and binding of reproductive steroids (1). A newer enzyme-inducing AED, topiramate (TPM), also has been shown to reduce serum OCP steroid levels at daily dosages of ≥200 mg (2). Clinically significant interactions… CONTINUE READING

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