Serum Valproate Levels with Oral Contraceptive Use

@article{Herzog2005SerumVL,
  title={Serum Valproate Levels with Oral Contraceptive Use},
  author={A. Herzog and E. L. Farina and A. Blum},
  journal={Epilepsia},
  year={2005},
  volume={46}
}
  • A. Herzog, E. L. Farina, A. Blum
  • Published 2005
  • Medicine
  • Epilepsia
  • It has long been recognized that the use of the older enzyme-inducing antiepileptic drugs (AEDs), such as barbiturates, phenytoin (PHT) and carbamazepine (CBZ), is associated with higher failure rates of oral contraceptive pills (OCPs), likely because of the induction of the catabolism and binding of reproductive steroids (1). A newer enzyme-inducing AED, topiramate (TPM), also has been shown to reduce serum OCP steroid levels at daily dosages of ≥200 mg (2). Clinically significant interactions… CONTINUE READING
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    References

    SHOWING 1-9 OF 9 REFERENCES
    Lamotrigine plasma levels reduced by oral contraceptives
    • 194
    • Highly Influential
    Interactions Between Antiepileptic Drugs and Hormonal Contraception
    • 154
    • Highly Influential
    Oral contraceptives reduce lamotrigine plasma levels
    • 222
    • Highly Influential
    Phenytoin pharmacokinetics in catamenial epilepsy
    • 116
    • Highly Influential
    Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
    • 183
    • Highly Influential
    • PDF
    Three Patterns of Catamenial Epilepsy
    • 431
    • PDF
    Pharmacokinetics and hormonal effects of lamotrigine-combined oral contraceptive co-administration
    • Epilepsia 2004;45(suppl 7):330. Epilepsia,
    • 2005
    Ethinyl estradiol, but not gestagens, reduces lamotrigine serum concentrations
    • Epilepsia
    • 2004