Serum Tumor Necrosis Factor-α and Interleukin-10 Levels as Markers to Predict Outcome of Patients with Chronic Lymphocytic Leukemia in Different Risk Groups Defined by the IGHV Mutation Status

@article{LechMaranda2012SerumTN,
  title={Serum Tumor Necrosis Factor-α and Interleukin-10 Levels as Markers to Predict Outcome of Patients with Chronic Lymphocytic Leukemia in Different Risk Groups Defined by the IGHV Mutation Status},
  author={Ewa E Lech-Maranda and Olga Grzybowska-Izydorczyk and Krystyna Wyka and Wojciech Mlynarski and Maciej Borowiec and Karolina Antosik and Barbara Cebula-Obrzut and Hanna Makuch-Lasica and Grażyna Nowak and Gabriela Klimkiewicz-Wojciechowska and Ewa Wawrzyniak and Przemyslaw Bilinski and Tadeusz Robak and Krzysztof Warzocha},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
  year={2012},
  volume={60},
  pages={477-486}
}
Tumor necrosis factor (TNF)-α and interleukin (IL)-10 are cytokines involved in the balance between cell-mediated and humoral immunity. We investigated whether serum TNF-α and IL-10 levels have any impact on clinical outcome of patients with chronic lymphocytic leukemia (CLL). TNF-α and IL-10 levels were determined in the serum of 160 CLL patients at the time of diagnosis. The cytokine low-risk group consisted of patients with either TNF-α and IL-10 levels below their medians or those with only… CONTINUE READING

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