Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden.

@article{Stubbs2016SerumTI,
  title={Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden.},
  author={Jason R. Stubbs and John A. House and Andrew J. Ocque and Shiqin Zhang and Cassandra Johnson and Cassandra Kimber and Kyle P Schmidt and Aditi Gupta and James B. Wetmore and Thomas D. Nolin and John A Spertus and Alan S L Yu},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 1},
  pages={305-13}
}
Trimethlyamine-N-oxide (TMAO) was recently identified as a promoter of atherosclerosis. Patients with CKD exhibit accelerated development of atherosclerosis; however, no studies have explored the relationship between TMAO and atherosclerosis formation in this group. This study measured serum concentrations and urinary excretion of TMAO in a CKD cohort (n=104), identified the effect of renal transplant on serum TMAO concentration in a subset of these patients (n=6), and explored the cross… CONTINUE READING