Serum Thymidine Kinase 1 Activity in the Prognosis and Monitoring of Chemotherapy in Lung Cancer Patients: A Brief Report

  title={Serum Thymidine Kinase 1 Activity in the Prognosis and Monitoring of Chemotherapy in Lung Cancer Patients: A Brief Report},
  author={Benjamin Nisman and Hovav Nechushtan and Haim Biran and Hadas Gantz-Sorotsky and Nir Peled and Simon Gronowitz and Tamar Peretz},
  journal={Journal of Thoracic Oncology},
Introduction: Thymidine kinase 1 (TK1) is a metabolic enzyme involved in DNA synthesis. Most standard treatment protocols for lung cancer (LC) include cytotoxic agents, which are potential modulators of TK1. We aimed to assess the prognostic significance of serum TK1 activity and its role in monitoring chemotherapy in LC patients. Methods: TK1 activity was measured using the DiviTum (Biovica) assay in sera from 233 patients with non–small-cell lung cancer (NSCLC), 91 with small-cell lung cancer… 

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