Serum NSE, MMP-9 and HER2 extracellular domain are associated with brain metastases in metastatic breast cancer patients: predictive biomarkers for brain metastases?

@article{Darlix2016SerumNM,
  title={Serum NSE, MMP-9 and HER2 extracellular domain are associated with brain metastases in metastatic breast cancer patients: predictive biomarkers for brain metastases?},
  author={Am{\'e}lie Darlix and P J Lamy and Evelyne Lopez-Crapez and Antoine Laurent Braccini and Nelly Firmin and Gilles H Romieu and Simon Th{\'e}z{\'e}nas and William Jacot},
  journal={International journal of cancer},
  year={2016},
  volume={139 10},
  pages={2299-311}
}
Breast cancer (BC) is the second most common cause of brain metastases (BM). Predictive factors for BM have been widely studied in metastatic BC; however, there is no known serum tumor marker to accurately predict BM. Elevated serum S100ß protein and neuron-specific enolase (NSE) could reflect the brain damages induced by BM. Matrix metalloproteinase 9 (MMP-9) is involved in tumor invasion and metastatic dissemination, including BM. Also, HER2-amplified BC were shown to have a particular… CONTINUE READING
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