Serum N-telopeptide and bone-specific alkaline phosphatase levels in patients with osteonecrosis of the jaw receiving bisphosphonates for bone metastases.

@article{Morris2012SerumNA,
  title={Serum N-telopeptide and bone-specific alkaline phosphatase levels in patients with osteonecrosis of the jaw receiving bisphosphonates for bone metastases.},
  author={Patrick Glyn Morris and Maurizio Fazio and Azeez Farooki and Cherry L. Estilo and Divya Mallam and Alison Conlin and Sujata Patil and M. Fleisher and Serge Cremers and Joseph M. Huryn and Clifford A. Hudis and Monica Nancy Fornier},
  journal={Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons},
  year={2012},
  volume={70 12},
  pages={2768-75}
}
PURPOSE Oversuppression of bone turnover can be a critical factor in the pathogenesis of osteonecrosis of the jaw (ONJ). We investigated N-telopeptide of type I collagen (NTX) and bone-specific alkaline phosphatase (BAP) as potential predictors of ONJ onset. PATIENTS AND METHODS Patients with ONJ and available stored serum were identified retrospectively from the institutional databases. Four approximate points were examined: point of ONJ diagnosis and 12, 6, and 1 month before the diagnosis… CONTINUE READING