Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.

@article{Liu2015SerumNI,
  title={Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.},
  author={Ming Liu and Lihua Li and Jihong Chu and Boyu Zhu and Qingtao Zhang and Xueyan Yin and Weimin Jiang and Guoliang Dai and Wen-zheng Ju and Zhenxing Wang and Qin Yang and Zhuyuan Fang},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2015},
  volume={100 8},
  pages={3112-7}
}
CONTEXT Nicotinamide N-methyltransferase (NNMT) is a novel histone methylation modulator that regulates energy metabolism, and NNMT knockdown prevents diet-induced obesity in mice. However, whether NNMT plays a role in human obesity and type 2 diabetes (T2DM) remains to be elucidated. OBJECTIVE NNMT catalyzes methylation of nicotinamide to generate N(1)-methylnicotinamide (me-NAM). We aimed to investigate the associations of serum me-NAM with obesity and T2DM in Chinese. DESIGN, SETTING… CONTINUE READING
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