Serum Matrix Metalloproteinase-7 Level is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy.

@article{Zhang2017SerumMM,
  title={Serum Matrix Metalloproteinase-7 Level is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy.},
  author={Jian Zhang and Pingping Ren and Yucheng Wang and Shi -Qing Feng and Cuili Wang and Xiujin Shen and Chunhua Weng and Xiaobing Lang and Zhiming Chen and Hong Jiang and Jianghua Chen},
  journal={Kidney & blood pressure research},
  year={2017},
  volume={42 3},
  pages={
          541-552
        }
}
BACKGROUND/AIMS In view of the latest findings that matrix metalloproteinase-7 (MMP-7) acted as a vital marker and pathogenic mediator of renal fibrosis in a murine model, we hypothesized that serum MMP-7 level might serve as a noninvasive prognostic biomarker in IgA nephropathy (IgAN) patients. METHODS We conducted a retrospective follow-up study of 244 IgAN patients for a median of 81.9 months. Serum MMP-7 was detected at the time of diagnosis, and renal progression was assessed by Cox… CONTINUE READING
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