Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

@inproceedings{Lavallard2011SerumMO,
  title={Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease},
  author={Vanessa Lavallard and St{\'e}phanie Bonnafous and St{\'e}phanie Patouraux and Marie-Christine Saint-Paul and D{\'e}borah Rousseau and Rodolphe Anty and Yannick Le Marchand-Brustel and Albert Tran and Philippe Gual},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Quantification of hepatocyte death is useful to evaluate the progression of alcoholic liver diseases. Our aims were to quantify and correlate the circulating levels of Cytokeratin 18 (CK18) and its caspases-generated fragment to disease severity in heavy alcoholics. METHODOLOGY/PRINCIPAL FINDINGS CK18 and CK18-fragment were evaluated in the serum of 143 heavy alcoholics. Serum levels of markers of hepatocyte death (CK18), apoptosis (CK18 fragment) and necrosis (CK18 -CK18 fragment… CONTINUE READING
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