Serum Interleukin-18 Levels Are Associated with Physical Activity in Japanese Men

Abstract

OBJECTIVE To investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men. METHODS A total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study. We assessed anthropometric and body composition parameters. Serum IL-18 levels, physical activity by uniaxial accelerometers, peak oxygen uptake and metabolic risk parameters were also evaluated. RESULTS Serum IL-18 levels were 179.4±84.7 pg/mL. Physical activity evaluated by Σ[metabolic equivalents × h per week (METs⋅h/w)]was significantly and negatively correlated with serum IL-18 levels (r = -0.252, p = 0.0235). These associations remained even after adjusting for age, peak oxygen uptake and other confounding factors. CONCLUSION Serum IL-18 levels were closely associated with physical activity independent of peak oxygen uptake in Japanese men.

DOI: 10.1371/journal.pone.0081497

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@inproceedings{Oda2013SerumIL, title={Serum Interleukin-18 Levels Are Associated with Physical Activity in Japanese Men}, author={Kanae Oda and Nobuyuki Miyatake and Noriko Sakano and Takeshi Saito and Motohiko Miyachi and Izumi Tabata and Takeyuki Numata}, booktitle={PloS one}, year={2013} }