Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41.

@article{Clerici2002SerumIO,
  title={Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41.},
  author={Mario Clerici and Claudia Barassi and Claudia Devito and Claudia Pastori and Stefania Piconi and Daria Lucia Trabattoni and Renato Longhi and Jorma Hinkula and Kristina Broliden and L Lopalco},
  journal={AIDS},
  year={2002},
  volume={16 13},
  pages={1731-41}
}
BACKGROUND HIV-specific IgA is present in HIV-exposed uninfected individuals (EU) and neutralizes primary strains of HIV-1 in vitro. OBJECTIVES To analyse the antigenic correlates of HIV-1 neutralization using HIV epitopes and IgA from EU and HIV-seropositive individuals. METHODS Sera from six heterosexual couples discordant for HIV serostatus, six age-matched HIV-infected subjects and six healthy controls (HC; as negative controls) were analysed. IgA binding on HIV Env recombinant proteins… CONTINUE READING

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