Serum IL10 and circulating CD4+CD25high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

@article{Alhamarneh2011SerumIA,
  title={Serum IL10 and circulating CD4+CD25high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma},
  author={Osama Alhamarneh and Frank O Agada and Leigh A. Madden and Nicholas D. Stafford and John Greenman},
  journal={Head \& Neck},
  year={2011},
  volume={33}
}
Patients with head and neck squamous cell carcinoma (HNSCC) commonly have an imbalance in T helper (Th)1/Th2‐type cytokines and elevated levels of CD4+CD25high regulatory T cells (Treg). Here, we investigated the association of circulating interleukin (IL)10, IL12, and Treg‐cells with clinical outcome in patients with HNSCC. 
Serum IL 10 , IL 12 and circulating CD 4 + CD 25 high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients
IL10, but not IL12 or T regulatory cells in the circulation of newly presenting, pre-treatment head and neck squamous cell carcinoma (HNSCC) patients, has been shown previously to be related toExpand
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References

SHOWING 1-10 OF 47 REFERENCES
Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer
TLDR
The data suggest that Treg in patients with SCCHN largely contain T cells with the ‘effector’ phenotype, which bind Annexin V and have low ζ expression, consistent with their activation state and a rapid turnover in the peripheral circulation. Expand
Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients.
TLDR
Assessment of the extent of immune dysfunction might help design immunotherapeutic protocols by incorporating any agent having immunomodulatory function and Dysregulation in the profile of immunocompetent cells and cytokine secretion was reflected in the suppressed cytotoxic function of HNSCC PBMCs. Expand
CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
TLDR
Results strongly suggest that tumor-related factors induce and expand CD4(+)CD25high T regs in PBMCs from patients with gastric and esophageal cancers in relation to the clinical outcome. Expand
T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease
TLDR
The Tr1 cell frequency and suppressor function were significantly higher in patients presenting with advanced than early disease stages and in patients “cured” by oncologic therapies than in those with active disease. Expand
The Frequency and Suppressor Function of CD4+CD25highFoxp3+ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck
TLDR
The frequency of T cells with suppressor phenotype and function (Treg) was significantly greater in HNSCC patients who were NED after oncologic therapy relative to those with active disease (AD). Expand
Decreased Absolute Counts of T Lymphocyte Subsets and Their Relation to Disease in Squamous Cell Carcinoma of the Head and Neck
TLDR
Patients with SCCHN have altered lymphocyte homeostasis, which persists for months or years after curative therapies, and the T-cell imbalance was evident many years afterCurative surgery. Expand
Modulation of Th1 and Th2 Cytokine Profiles and Their Association with Advanced Head and Neck Squamous Cell Carcinoma
TLDR
Patients with advanced HNSCC have a potentially diminished Th1 immune response, and a stronger potential Th2 immune response when compared to that of patients with less advanced disease. Expand
Increased aberrance of cytokine expression in plasma of patients with more advanced squamous cell carcinoma of the head and neck.
TLDR
Results show a partial Th2 cytokine bias in HNSCC patients and a progressively more aberrant expression of cytokines with more advanced disease. Expand
Differential regulation of IL-2 and IL-4 in patients with tobacco-related oral squamous cell carcinoma.
TLDR
The tobacco-related intraoral squamous cell carcinoma seems to be associated with multiple systemic immune defects particularly, an impaired CD3+ and CD4+ T cells in the peripheral blood as well as a differential regulation of IL-2 and IL-4 in CD4 and CD8+ T-cell subsets. Expand
Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck.
TLDR
Results suggest skewing toward a Th2 bias in HNSCC patients, with the Th2 shift being incomplete and indicative of the presence, rather than the extent, of malignant disease. Expand
...
1
2
3
4
5
...