Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity

@article{BahramiMahneh2015SerumII,
  title={Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity},
  author={Sedigheh Bahrami Mahneh and Masoud Movahedi and Zahra Aryan and Mohammad Ali Bahar and Arezou Rezaei and Maryam Sadr and Nima Rezaei},
  journal={International Archives of Allergy and Immunology},
  year={2015},
  volume={168},
  pages={193 - 196}
}
Background: The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. Objectives: This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. Methods: This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between… 

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References

SHOWING 1-10 OF 20 REFERENCES
Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children
TLDR
Values of sST2 and IL-33 observed in IS were found to correlate with disease activity, and reflected the inflammatory process observed in the lung of young asthmatics.
Serum levels of IL-10, IL-17F and IL-33 in patients with asthma: a case–control study
TLDR
Negative correlation between IL-10 and IL-33 levels may reflect a converse relationship between anti-inflammatory and pro-inflammatory cytokines in an individually balanced pattern.
IL-33 promotes airway remodeling and is a marker of asthma disease severity
TLDR
IL-33 is a marker of asthma severity, and may contribute to airway remodeling in asthma by acting on human lung fibroblasts, according to real-time polymerase chain reactions and western blotting analysis.
Elevated Levels of Interleukin-33 in the Nasal Secretions of Patients with Allergic Rhinitis
TLDR
The results suggest that IL-33 in nasal secretions may be related to exacerbation of AR, including that of Japanese cedar pollinosis cases.
IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma.
Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity
TLDR
Elevated level of IL-33 in sera of patients with IAR sensitive to tree and/or grass pollen and the correlation ofIL-33 with the disease severity suggest that IL- 33 is involved in the pathogenesis of intermittent allergic rhinitis.
Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells1
TLDR
The data propose IL-33 as a novel inflammatory marker of severe and refractory asthma as well as subjects with asthma severity because ASMC are a source of the IL- 33 cytokine.
Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33
IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo.
TLDR
IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Expression and Effects of IL-33 and ST2 in Allergic Bronchial Asthma: IL-33 Induces Eotaxin Production in Lung Fibroblasts
TLDR
IL-33 may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts byacting on IL-33 and IL-13 synergistically induced eotaxin expression.
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