Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity

  title={Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity},
  author={Sedigheh Bahrami Mahneh and Masoud Movahedi and Zahra Aryan and Mohammad Ali Bahar and Arezou Rezaei and Maryam Sadr and Nima Rezaei},
  journal={International Archives of Allergy and Immunology},
  pages={193 - 196}
Background: The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. Objectives: This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. Methods: This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between… 

Figures and Tables from this paper

Relation of Serum Interleukin-33 level to Disease Severity in Asthmatic Patients
Serum IL-33 is in direct relation to disease severity in asthmatic patients and is higher in atopic asthmatics than in non-atopic patients.
Comparation between serum levels of interleukin-33 in children with allergic asthma before and after inhalatory corticosteroid treatment
Six-month treatment with ICS Th leads to significant reduction of IL-33 serum levels, whose values are in positive correlation with the severity and control of AA.
Changes in the Th9 cell population and related cytokines in the peripheral blood of infants with recurrent wheezing
It is suggested that the percentage of Th 9 cells is increased in infants with recurrent wheezing; thus, Th9 cells may play an important role in the pathogenesis of recurrent wheazing.
Seasonal Exacerbation of Asthma Is Frequently Associated with Recurrent Episodes of Acute Urticaria
It is demonstrated, for the first time, that asthma patients frequently develop acute urticaria, mainly during seasonal exacerbations, in contrast, CSU patients do not show an increased incidence of asthma.
TIPE 2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma
The results of the current study indicated that anti‐inflammatory TIPE2 levels are associated with levels of the coagulation substances TF and TSP‐1, however, further studies are required to determine whether TIPe2 participates in the pathogenesis of asthma by interacting with the coAGulation substancesTF and T SP‐1.


Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children
Values of sST2 and IL-33 observed in IS were found to correlate with disease activity, and reflected the inflammatory process observed in the lung of young asthmatics.
Serum levels of IL-10, IL-17F and IL-33 in patients with asthma: a case–control study
Negative correlation between IL-10 and IL-33 levels may reflect a converse relationship between anti-inflammatory and pro-inflammatory cytokines in an individually balanced pattern.
IL-33 promotes airway remodeling and is a marker of asthma disease severity
IL-33 is a marker of asthma severity, and may contribute to airway remodeling in asthma by acting on human lung fibroblasts, according to real-time polymerase chain reactions and western blotting analysis.
Elevated Levels of Interleukin-33 in the Nasal Secretions of Patients with Allergic Rhinitis
The results suggest that IL-33 in nasal secretions may be related to exacerbation of AR, including that of Japanese cedar pollinosis cases.
IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma.
Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity
Elevated level of IL-33 in sera of patients with IAR sensitive to tree and/or grass pollen and the correlation ofIL-33 with the disease severity suggest that IL- 33 is involved in the pathogenesis of intermittent allergic rhinitis.
Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells1
The data propose IL-33 as a novel inflammatory marker of severe and refractory asthma as well as subjects with asthma severity because ASMC are a source of the IL- 33 cytokine.
Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33
IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo.
IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Expression and Effects of IL-33 and ST2 in Allergic Bronchial Asthma: IL-33 Induces Eotaxin Production in Lung Fibroblasts
IL-33 may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts byacting on IL-33 and IL-13 synergistically induced eotaxin expression.