Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population.

@article{Zhang2016SerumIL,
  title={Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population.},
  author={Xiang Yang Zhang and Yun-long Tan and Da-Chun Chen and Shu-ping Tan and Michelle Z Malouta and Jared D Bernard and Jessica L Combs and Sarai Bhatti and Michael C Davis and Thomas R. Kosten and Jair C. Soares},
  journal={Psychoneuroendocrinology},
  year={2016},
  volume={68},
  pages={140-7}
}
Literature suggests that alterations in the inflammatory and immune systems are involved in the pathogenesis of schizophrenia. Specifically, patients diagnosed with schizophrenia exhibit increased IL-18, a pleiotropic proinflammatory cytokine in type 1 T-helper (Th1) responses. The functional 607A/C promoter polymorphism of the IL-18 gene is also associated with the psychopathology of this disorder. However, no current study has explored its role in the clinical symptoms of schizophrenia as… CONTINUE READING
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