Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis

  title={Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis},
  author={A. Sansone and A. Cignarelli and M. Sansone and F. Romanelli and G. Corona and D. Gianfrilli and A. Isidori and F. Giorgino and A. Lenzi},
  journal={International Journal of Endocrinology},
Objectives Elevated levels of serum homocysteine (Hcy) have been associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). This meta-analysis was aimed to assess serum Hcy levels in subjects with ED compared to controls in order to clarify the role of Hcy in the pathogenesis of ED. Methods Medline, Embase, and the Cochrane Library were searched for publications investigating the possible association between ED and Hcy… Expand
Novel predictive risk factor for Erectile Dysfunction: Serum folic acid
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Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case–control study
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The analysis demonstrated that arginine supplements with dosage ranging from 1,500 to 5,000 mg significantly improved ED compared with placebo or no treatment, and can be recommended to patients with mild to moderate ED. Expand
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Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
This review focuses on the biological processes that lead to homocysteine-induced endothelial damage and discusses the consequences of HHcys on male sexual function. Expand
Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model.
Erectile function was significantly reduced in the rats with HHcy compared with that in the control group and was ameliorated in the HHcy rats treated with Mel, providing evidence that Mel could be a potential therapeutic method for HHcy-related ED. Expand
Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case‐control study
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People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction
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Addressing male sexual and reproductive health in the wake of COVID-19 outbreak
COVID-19 survivors might develop sexual and reproductive health issues and treatment with phosphodiesterase-5 (PDE5) inhibitors might be beneficial for both CO VID-19 and ED. Expand
Inconsistencies are common between non-Cochrane systematic reviews and their protocols registered in the International prospective register of systematic reviews ( PROSPERO ) but were seldom explained
Kaiyan Hu Lanzhou University Ting Zhang Lanzhou University Weiyi Zhang Lanzhou University Qi Zhou Lanzhou University Mengyao Jiang New Lanzhou University Joey S.W. Kwong Chinese University of HongExpand


Hyperhomocysteinemia is a risk factor for erectile dysfunction in men with adult-onset diabetes mellitus.
High plasma tHcy appears to be associated with ED in patient with adult-onset diabetes mellitus, and the risk of ED did not vary significantly according to body mass index, serum cholesterol, triglycerides, C-reactive protein, and blood HbA1c levels, but was significantly affected by smoking status and hypertension. Expand
Elevated serum homocysteine level as an independent risk factor for erectile dysfunction: a prospective pilot case–control study
Data suggested that elevation of homocysteine levels was associated with an increased risk of ED, especially for vasculogenic ED, and mild, moderate and severe ED occurrence. Expand
Folate: a possible role in erectile dysfunction?
Lack of correlation between FA and Hcys suggests that FA deficit may directly impair EF, and a significant association among ED, FA deficiency and hyperomocisteinemia is showed. Expand
Association of homocysteine with type 1 diabetes mellitus: a meta-analysis.
The meta-analysis indicated that plasma Hcy concentrations in T1DM patients without any complications were normal compared with healthy people, and homocysteine levels elevate in T2DM patients with DR and DN, but don't elevate inT1DM withoutAny complications. Expand
A possible new risk factor in diabetic patients with erectile dysfunction: homocysteinemia.
It is concluded that traditional risk factors, poor metabolic control, and smoking are important in ED generation in diabetic patients. Expand
Cigarette smoking as risk factor for erectile dysfunction: results from an Italian epidemiological study.
The risk of ED is influenced by smoking and that the duration of the habit increases the risk, and the potential interaction of smoking with medical history on ED risk is highlighted. Expand
Serum homocysteine levels and sildenafil 50 mg response in young-adult male patients without vascular risk factors.
Results indicated that measurement of serum homocysteine levels could be used as a marker for the evaluation of efficacy of phosphodiesterase 5 inhibitor and the selection of efficacious alternative therapies. Expand
Hyperhomocysteinemia: a novel risk factor for erectile dysfunction.
The data suggest that slightly elevated Hcys levels are significantly related with arterial and probably endothelial dysfunction in patients with ED, and Hyperhomocysteinemia seems to be an important determinant in ED. Expand
A new potential risk factor in patients with erectile dysfunction and premature ejaculation: folate deficiency
Findings showed a strong relationship between serum FA levels and sexual dysfunction, possibly due to an effect of FA on the metabolism of nitric oxide, Hcys, and 5-hydroxytryptamine. Expand
Homocysteine, renal function, and risk of cardiovascular disease.
The concordance of the IHD risks obtained in the studies of genetically determined differences in homocysteine and the population-based studies of homocy steine suggest that these associations are likely to be causal. Expand