Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis

@article{Sansone2018SerumHL,
  title={Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis},
  author={A. Sansone and A. Cignarelli and M. Sansone and F. Romanelli and G. Corona and D. Gianfrilli and A. Isidori and F. Giorgino and A. Lenzi},
  journal={International Journal of Endocrinology},
  year={2018},
  volume={2018}
}
Objectives Elevated levels of serum homocysteine (Hcy) have been associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). This meta-analysis was aimed to assess serum Hcy levels in subjects with ED compared to controls in order to clarify the role of Hcy in the pathogenesis of ED. Methods Medline, Embase, and the Cochrane Library were searched for publications investigating the possible association between ED and Hcy… Expand
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Kaiyan Hu Lanzhou University Ting Zhang Lanzhou University Weiyi Zhang Lanzhou University Qi Zhou Lanzhou University Mengyao Jiang New Lanzhou University Joey S.W. Kwong Chinese University of HongExpand

References

SHOWING 1-10 OF 51 REFERENCES
Hyperhomocysteinemia is a risk factor for erectile dysfunction in men with adult-onset diabetes mellitus.
TLDR
High plasma tHcy appears to be associated with ED in patient with adult-onset diabetes mellitus, and the risk of ED did not vary significantly according to body mass index, serum cholesterol, triglycerides, C-reactive protein, and blood HbA1c levels, but was significantly affected by smoking status and hypertension. Expand
Elevated serum homocysteine level as an independent risk factor for erectile dysfunction: a prospective pilot case–control study
TLDR
Data suggested that elevation of homocysteine levels was associated with an increased risk of ED, especially for vasculogenic ED, and mild, moderate and severe ED occurrence. Expand
Folate: a possible role in erectile dysfunction?
TLDR
Lack of correlation between FA and Hcys suggests that FA deficit may directly impair EF, and a significant association among ED, FA deficiency and hyperomocisteinemia is showed. Expand
Association of homocysteine with type 1 diabetes mellitus: a meta-analysis.
TLDR
The meta-analysis indicated that plasma Hcy concentrations in T1DM patients without any complications were normal compared with healthy people, and homocysteine levels elevate in T2DM patients with DR and DN, but don't elevate inT1DM withoutAny complications. Expand
A possible new risk factor in diabetic patients with erectile dysfunction: homocysteinemia.
TLDR
It is concluded that traditional risk factors, poor metabolic control, and smoking are important in ED generation in diabetic patients. Expand
Cigarette smoking as risk factor for erectile dysfunction: results from an Italian epidemiological study.
TLDR
The risk of ED is influenced by smoking and that the duration of the habit increases the risk, and the potential interaction of smoking with medical history on ED risk is highlighted. Expand
Serum homocysteine levels and sildenafil 50 mg response in young-adult male patients without vascular risk factors.
TLDR
Results indicated that measurement of serum homocysteine levels could be used as a marker for the evaluation of efficacy of phosphodiesterase 5 inhibitor and the selection of efficacious alternative therapies. Expand
Hyperhomocysteinemia: a novel risk factor for erectile dysfunction.
TLDR
The data suggest that slightly elevated Hcys levels are significantly related with arterial and probably endothelial dysfunction in patients with ED, and Hyperhomocysteinemia seems to be an important determinant in ED. Expand
A new potential risk factor in patients with erectile dysfunction and premature ejaculation: folate deficiency
TLDR
Findings showed a strong relationship between serum FA levels and sexual dysfunction, possibly due to an effect of FA on the metabolism of nitric oxide, Hcys, and 5-hydroxytryptamine. Expand
Homocysteine, renal function, and risk of cardiovascular disease.
TLDR
The concordance of the IHD risks obtained in the studies of genetically determined differences in homocysteine and the population-based studies of homocy steine suggest that these associations are likely to be causal. Expand
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