Serum Homocysteine, Folate, and Vitamin B12 Levels in Carbamazepine Treated Epileptic Children.

@article{Sharma2016SerumHF,
  title={Serum Homocysteine, Folate, and Vitamin B12 Levels in Carbamazepine Treated Epileptic Children.},
  author={Tarun Kumar Sharma and Satish Kumar Vardey and Shanthi V. Sitaraman},
  journal={Clinical laboratory},
  year={2016},
  volume={62 7},
  pages={
          1217-1224
        }
}
BACKGROUND Antiepileptic drugs (AEDs) have been associated with metabolic consequences that lead to an increase in risk of atherosclerosis in patients with epilepsy. Therefore, we evaluated whether differences exist in homocysteine, folate, and vitamin B12 levels in children receiving carbamazepine (CBZ) monotherapy. METHODS A total of 58 newly diagnosed epileptic children with ages ranging from 2 to 15 years were enrolled at the start of study. However, after 3 months follow up, the final… 

Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children.

Phenytoin monotherapy may cause a significant increase in the levels of serum homocysteine and a significant decrease in the serum folate and vitamin B12 levels in children with epilepsy, and the significant changes in above mentioned parameters occur early in the course of treatment.

An update on the problem of osteoporosis in people with epilepsy taking antiepileptic drugs

Evidence related to the deteriorating influence of AEDs on bone, demonstrating generally stronger negative effects of conventional AED’s, is discussed.

Management of antiepileptic drug–induced nutrition-related adverse effects

The adverse effects of AEDs on some of the nutrition-related issues, including bone health, body weight, glucose and lipid metabolism, vitamin homeostasis, antioxidant defense system, and pregnancy are reviewed.

Drug-Induced Male Osteoporosis

In this chapter the essential characteristics of the various osteo-active drugs and their action on the bone status are briefly described.

Medicines associated with folate–homocysteine–methionine pathway disruption

This review focuses on prescription medicines associated with folate disruption and summarizes their undesirable/toxic effects and recommendations regarding folate supplementation during medical therapy.