Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.

@article{Kong2016SerumEA,
  title={Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.},
  author={So Yeon Joyce Kong and Hao Quang Tran and Andrew T. Gewirtz and Gail Elizabeth McKeown-Eyssen and Veronika Fedirko and Isabelle Romieu and Anne Tj\onneland and Anja Olsen and Kim Overvad and Marie-Christine Boutron-Ruault and Nadia M. Bastide and Aur{\'e}lie Affret and Tilman K{\"u}hn and Rudolf Kaaks and Matthias B Schulze and Krasimira Aleksandrova and Antonia Trichopoulou and Maria Kritikou and Effie Vasilopoulou and Domenico Palli and Vittorio Krogh and Amalia Mattiello and Rosario Tumino and Alessio Naccarati and H B as Bueno-de-Mesquita and Petra H. M. Peeters and Elisabete Weiderpass and Jos{\'e} Ram{\'o}n Quir{\'o}s and N{\'u}ria Sala and Mar{\'i}a Jos{\'e} Yuste S{\'a}nchez and Jos{\'e} M. Casta{\~n}o and Aurelio Barricarte and Miren Dorronsoro and M{\aa}rten Werner and Nicholas J Wareham and Kay-Tee Khaw and Kathryn E Bradbury and Heinz Freisling and F. Stavropoulou and Pietro Ferrari and Marc J. Gunter and Amanda J. Cross and Elio Riboli and Walter R. Bruce and M. Jenab},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2016},
  volume={25 2},
  pages={291-301}
}
BACKGROUND Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody levels and colorectal cancer risk. METHODS A total of 1,065 incident colorectal cancer cases (colon… CONTINUE READING