Serum Dickkopf 1 levels in sclerostin deficiency.


CONTEXT Sclerostin and Dickkopf 1 (DKK1) are antagonists of the canonical Wnt signaling pathway, both binding to the same low-density lipoprotein receptor-related protein 5/6 on osteoblasts, thereby inhibiting bone formation. It is not known whether there is an interaction between sclerostin and DKK1. OBJECTIVE We examined whether a lack of sclerostin is… (More)
DOI: 10.1210/jc.2013-3278


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