Serum Concentrations of Salicylic Acid following Topically Applied Salicylate Derivatives

@article{Morra1996SerumCO,
  title={Serum Concentrations of Salicylic Acid following Topically Applied Salicylate Derivatives},
  author={Paola Morra and Wm. R. Bartle and Scott E. Walker and S N Lee and Susan K. Bowles and Richard A. Reeves},
  journal={Annals of Pharmacotherapy},
  year={1996},
  volume={30},
  pages={935 - 940}
}
OBJECTIVE: To compare the rate and extent of systemic salicylate absorption following single and multiple applications of two topically applied analgesics, one containing methyl salicylate and the other containing trolamine salicylate. DESIGN: Two-period, two-treatment, randomized, crossover, multiple-dose study in healthy men and women volunteers. PARTICIPANTS: Six men and six women volunteers, 21–14 years of age. INTERVENTIONS: Subjects applied 5 g of an ointment containing 12.5% methyl… 

Figures and Tables from this paper

A Volunteer Study on the Blood Salicylate Level of Excessive Use of Topical Methylsalicylate
TLDR
Dermal application of massive amount of analgesic balm may cause unpredictable absorption of methylsalicylate, and patients and physicians should be aware of its potential risk.
Comparison of Oral Aspirin Versus Topical Applied Methyl Salicylate for Platelet Inhibition
TLDR
Topical methyl salicylate and oral aspirin both significantly decrease platelet aggregation in healthy human volunteers.
Topical delivery of salicylates.
TLDR
Both passive and active strategies, including emerging technologies employed to enhance skin permeation of these two salicylate compounds are summarised, which targets the drug retention in and on the skin based on the different indications.
Topical Acne Drugs
TLDR
Animal data support avoidance of many topical agents, particularly known teratogens such as retinoids and salicylic acid, in pregnant women, and recommend caution in special circumstances, such as during childhood, pregnancy, lactation and concomitant therapy with other drugs, because relevant studies are lacking.
The Pharmacology of Topical Analgesics
TLDR
The mechanisms of action, pharmacokinetics, and tolerability of topical treatments for the management of patient pain are reviewed and some adverse events that have been observed in patients may be suggestive of some degree of systemic exposure.
Self Promotion of Deep Tissue Penetration and Distribution of Methylsalicylate After Topical Application
TLDR
In vivo tissue and plasma concentrations of salicylate in rats rose rapidly in the first 1 hr and were more than the predicted 1.4-fold higher for MeSA, mirrored by the increase in blood flow induced by MeSA in human cutaneous vessels and that reported in the literature.
Penetration of a topically applied nonsteroidal anti-inflammatory drug into local tissues and synovial fluid of dogs.
TLDR
Topically applied NSAIDs can penetrate deeply into tissues and synovial fluid and local concentrations higher than circulating systemic concentrations are suggestive that direct diffusion and local blood redistribution are contributing to this effect.
Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
TLDR
The absorption and tissue concentration profiles for the commercial methylsalicylate formulation are indicative of direct tissue penetration and not solely redistribution by the systemic blood supply.
Topical Therapies for Osteoarthritis
TLDR
Topical NSAIDs have been available in Europe for decades and were introduced to provide localized analgesia with minimal systemic NSAID exposure, but neither has shown substantial efficacy in clinical trials, and both have potential to cause serious AEs.
Topical Therapy for Osteoarthritis: Clinical and Pharmacologic Perspectives
TLDR
Clinical trial data suggest that diclofenac sodium 1% gel provides clinically meaningful analgesia in OA patients with a low incidence of systemic AEs.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
Absorption of Labeled Triethanolamine Salicylate in Human and Canine Knee Joints. II
TLDR
During transdermal absorption of TEA/S, the salt may disassociate; this could permit the salicylate to have a longer transit time in the area of application.
Warfarin and topical salicylates.
To the Editor.— Two patients who were receiving maintenance warfarin therapy and who experienced marked prolongation of the prothrombin time by topical nonprescription medications are described.
Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard.
TLDR
It is concluded that topical methylsalicylate ointment should be prescribed with care to patients on warfarin and excessive usage is to be avoided since potentially dangerous drug interaction could occur.
Salicylates in foods.
TLDR
This is the most comprehensive set of data on food salicylates yet published; extraction appears to have been more complete for some foods, giving higher values than those previously published.
Potentiation of Warfarin Anticoagulation by Topical Methylsalicylate Ointment
TLDR
Although no evidence of viral infection was found in the authors' patient the histological appearance of the myocardium suggests the possibility of a viral aetiology for the disease.
Simultaneous liquid-chromatographic quantitation of salicylic acid, salicyluric acid, and gentisic acid in plasma.
TLDR
This method estimates salicylic acid and metabolites within 12 mm; the limit of detection is 3 ng; the method saw no interference in sara from patients being treated with various drugs other than aspirin.
Drug biotransformation interactions in man. I. Mutual inhibition in glucuronide formation of salicylic acid and salicylamide in man.
TLDR
The results of this study indicate that concomitant use of certain drugs which are readily available to the public may lead to appreciable interactions in biotransformation and to enhanced pharmacologic effects.
Food sensitivity.
TLDR
In affluent countries the idea is now widespread that a variety of symptoms are caused by individual (hyper)sensitivity to certain foods or substances in them; that such sensitivity has become more common; and that food processing has something to do with it.
Sample size calculations for clinical pharmacology studies
Clinical Pharmacology and Therapeutics (1986) 39, 489–490; doi:10.1038/clpt.1986.85
Statistical Methods
P > 0.05 0.01 < P < 0.05 0.001 < P < 0.01 * * * multiple regression analyses were tested by t tests. Regression lines were compared by means of analysis of covariance in which differences in slopes
...
1
2
3
...