Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome.

@article{Bargoma2005SerumCP,
  title={Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome.},
  author={Emilee M Bargoma and Joyce K Mitsuyoshi and Sandra K. Larkin and Lori A Styles and Frans A. Kuypers and Samuel T Test},
  journal={Blood},
  year={2005},
  volume={105 8},
  pages={3384-5}
}
Previous studies from our institution have shown that serum secretory phospholipase A2 (sPLA2) levels are markedly increased in sickle cell disease (SCD) patients with acute chest syndrome (ACS)1 and that sequential measurements of sPLA2 are useful in predicting the subsequent development of ACS in patients hospitalized for vasoocclusive crisis (VOC).2 However, sPLA2 assays are not widely available in clinical laboratories. Thus, we sought a surrogate marker that might be measured instead of… CONTINUE READING
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