Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults: a cohort study.

@article{Boer2012Serum2D,
  title={Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults: a cohort study.},
  author={Ian H de Boer and Gregory Matthew Levin and Cassianne Robinson-Cohen and Mary Louise Biggs and Andy N. Hoofnagle and David S Siscovick and Bryan R Kestenbaum},
  journal={Annals of internal medicine},
  year={2012},
  volume={156 9},
  pages={
          627-34
        }
}
BACKGROUND Circulating concentrations of 25-hydroxyvitamin D [25-(OH)D] are used to define vitamin D deficiency. Current clinical 25-(OH)D targets based on associations with intermediate markers of bone metabolism may not reflect optimal levels for other chronic diseases and do not account for known seasonal variation in 25-(OH)D concentration. OBJECTIVE To evaluate the relationship of 25-(OH)D concentration with the incidence of major clinical disease events that are pathophysiologically… CONTINUE READING

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