Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS

@inproceedings{Savastano2011Serum2D,
  title={Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS},
  author={Silvia Savastano and Rossella Valentino and Carolina Di Somma and Francesco Orio and Claudia Pivonello and Federica Passaretti and Valentina Brancato and Pietro Formisano and Annamaria Colao and Francesco B{\'e}guinot and Giovanni Tarantino},
  booktitle={Nutrition & metabolism},
  year={2011}
}
BACKGROUND Polycystic ovary syndrome (PCOS) is frequently associated with hypovitaminosis D. Vitamin D is endowed with pleiotropic effects, including insulin resistance (IR) and apoptotic pathway. Disruption of the complex mechanism that regulated ovarian apoptosis has been reported in PCOS. Phosphoprotein enriched in diabetes gene product (PED/PEA-15), an anti-apoptotic protein involved in type 2 diabetes mellitus (T2DM), is overexpressed in PCOS women, independently of obesity. Leptin-to… CONTINUE READING
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