Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community.


BACKGROUND  Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. METHODS AND RESULTS  A total of 2,417 community-dwelling individuals without CKD stage 3-5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3-5, defined as estimated glomerular filtration rate (eGFR) <60ml·min(-1)·1.73m(-2), and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3-5. The age- and sex-adjusted incidence of CKD stage 3-5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3-5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR (-0.10ml·min(-1)·1.73m(-2)·year(-1) per 10-pg/ml decrement in serum 1,25(OH)2D). CONCLUSIONS  Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3-5 in the general Asian population. 

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@article{Izumaru2014Serum1D, title={Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community.}, author={Kensuke Izumaru and Toshiharu Ninomiya and Masaharu Nagata and Tomoko Usui and D Yoshida and Koji Yonemoto and Masayo Fukuhara and Kazuhiko Tsuruya and Takanari Kitazono and Yutaka Kiyohara}, journal={Circulation journal : official journal of the Japanese Circulation Society}, year={2014}, volume={78 3}, pages={732-7} }