Serum‐mediated transgenerational effects on sperm: Evidence for lamarckian inheritance?

  title={Serum‐mediated transgenerational effects on sperm: Evidence for lamarckian inheritance?},
  author={Y. Seki},
  • Y. Seki
  • Published 2013
  • Biology, Medicine
  • Hepatology
  • We investigated whether ancestral liver damage leads to heritable reprogramming of hepatic wound healing in male rats. We found that a history of liver damage corresponds with transmission of an epigenetic suppressive adaptation of the fibrogenic component of wound healing to the male F1 and F2 generations. Underlying this adaptation was less generation of liver myofibroblasts, higher hepatic expression of the antifibrogenic factor peroxisome proliferator-activated receptor g (PPAR-g) and lower… CONTINUE READING
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