Serum, urine and peritoneal fluid levels of 5-FU following intraperitoneal administration.

@article{Campora1987SerumUA,
  title={Serum, urine and peritoneal fluid levels of 5-FU following intraperitoneal administration.},
  author={Elisabetta Campora and Mauro Esposito and Dario Civalleri and L Gogioso and Franco Decian and N Balletto and Alfredo Falcone and Maria Teresa Nobile and Brunella Parodi and Sergio Cafaggi},
  journal={Anticancer research},
  year={1987},
  volume={7 4B},
  pages={829-32}
}
Seven patients with advanced colon cancer, refractory to conventional chemotherapy, and malignant disease confined to the intra-abdominal space received a total of 24 consecutive courses of ip 5-Fluorouracil (5-FU). 5-FU 1000 mg was administered in 2 L of warm (37 degrees C) dialysate daily for five consecutive days every 28 days. 5-FU concentrations in serum, peritoneal fluid and urine were measured by high pressure liquid chromatography (HPLC). The mean disappearance half-life of 5-FU from… CONTINUE READING