Serum, cerebrospinal fluid, and brain levels of bile acids in patients with fulminant hepatic failure.

@article{Bron1977SerumCF,
  title={Serum, cerebrospinal fluid, and brain levels of bile acids in patients with fulminant hepatic failure.},
  author={Bernhard Bron and R. P. L. Waldram and David B A Silk and Robert N. Williams},
  journal={Gut},
  year={1977},
  volume={18 9},
  pages={
          692-6
        }
}
Bile acid levels were measured in the sera, cerebrospinal fluid (CSF), and brain tissue of 10 patients immediately after death from fulminant hepatic (FHF). Serum bile acids in FHF were predominantly conjugated, and total bile acid levels were higher in all 10 patients than in normal controls (85.9 +/- SE 8.4 compared with 5.7 +/- 0.4 nmol/ml, P less than 0.001). Small but significant amounts could be detected in CSF (range 1.2-5.3 nmol total bile acid/ml) and brain biopsies (1.0-18.8 nmol/g… CONTINUE READING

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