Sertraline versus imipramine treatment of comorbid panic disorder and major depressive disorder.

@article{Lepola2003SertralineVI,
  title={Sertraline versus imipramine treatment of comorbid panic disorder and major depressive disorder.},
  author={Ulla M Lepola and M. Arat{\'o} and Young Zhu and Carol A Austin},
  journal={The Journal of clinical psychiatry},
  year={2003},
  volume={64 6},
  pages={654-62}
}
OBJECTIVE To evaluate the efficacy and tolerability of sertraline and imipramine in patients with comorbid panic disorder and major depressive disorder. METHOD Outpatients meeting a DSM-IV diagnosis of panic disorder and concurrent major depressive disorder were randomized in a 2:1 ratio to 26 weeks of double-blind treatment with either sertraline, in daily doses of 50 to 100 mg, or imipramine, in daily doses of 100 to 200 mg. Primary outcome measures were panic attack frequency (derived from… CONTINUE READING