Sertraline safety and efficacy in major depression: A double-blind fixed-dose comparison with placebo

@article{Fabre1995SertralineSA,
  title={Sertraline safety and efficacy in major depression: A double-blind fixed-dose comparison with placebo},
  author={Louis F. Fabre and Faruk S. Abuzzahab and M. Amin and James L. Claghorn and Joseph Mendels and William Matthew Flinders Petrie and Sanjay Dub{\'e} and Joyce Graham Small},
  journal={Biological Psychiatry},
  year={1995},
  volume={38},
  pages={592-602}
}
Escitalopram versus sertraline in the treatment of major depressive disorder: a randomized clinical trial*
TLDR
No differences in efficacy were observed for fixed-dose escitalopram 10 mg/day and sertraline flexibly dosed from 50–200  mg/day, and both treatments were generally well tolerated.
A placebo-controlled, randomized withdrawal study of sertraline for major depressive disorder in Japan
TLDR
Results confirm the efficacy of sertraline in preventing the relapse of MDD in Japanese patients and mean changes from beginning to end of the double-blind phase on measure of depressive symptoms, quality of life and global improvement also significantly favoured sERTraline over placebo.
Dose–response relationship of duloxetine in placebo-controlled clinical trials in patients with major depressive disorder
TLDR
In this assessment of patients with MDD, the HAM-D6 was shown to be more sensitive compared with theHAM-D17 at detecting treatment effects, and findings support that duloxetine 60 mg daily is the best effective dose.
The antidepressant effect of sertraline is not enhanced by dose titration: results from an outpatient clinical trial
TLDR
The results suggest that for most patients continued treatment with 50 mg dose of sertraline yields a rate of antidepressant response that is comparable to what is achieved by dose escalation from 50 mg to 150 mg of sERTraline after 3 weeks of treatment.
An Open Study of Sertraline in Acute and Continuation Treatment of Depressed Out-Patients
TLDR
The results of this open study are consistent with those of controlled studies in which sertraline was effective and well tolerated, in acute and continuation treatment for major depression, at 50 mg/day in most patients.
Efficacy between sertraline GPO and the original drug in treatment of major depressive disorder
TLDR
There were no differences in efficacy between sertraline GPO and the original drug in treatment of major depressive disorder and there were some limitations of this study.
Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder.
TLDR
The results of the current study suggest that sertraline is a safe, well-tolerated, and significantly effective treatment for PTSD.
A 12-week study comparing moclobemide and sertraline in the treatment of outpatients with atypical depression
TLDR
Both sertraline and moclobemide improved the symptoms of atypical depression in this study and were well tolerated.
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